Almost all newer Toyota and Lexus vehicles have subwoofer placed there. Great location IMO. Most subs from OEMs are the inverted type...so, very little depth is needed...so, they can fit literally anywhere!
The way most Lexus/Toyota OEMs (at least the higher ends) setup is to have a small subwoofer in the back/cargo to provide bass for the rear passengers...and minimally, provide a little oomph for front passengers. The bass for the front passengers is provided mostly by the front lower door woofers, which are usually oversized 6.5" or 6x9 variety. They provide most of the bass frequencies...the sub far in the cargo area is just to augment it (minimally). My guess is that the front door woofers (on 10-speaker setup) provide bass and no vocals...can you guys check? Vocals come from the midranges and tweeters in the dash above. Basically, the front passengers have a 3-way setup...tweeter, midrange, and bass/sub. So, technically, for front passengers, there is no need for the subwoofer in the cargo area except for maybe the deepest of bass...and even then, the cargo sub is only to supplement the bass pumped out by the front door woofers.
The rear doors has a midrange/tweeter combo and provide vocals only. Therefore, you need the subwoofer in the cargo area to supplement.
Toyota/Lexus a few years ago has gone to this type of setup...they called DSS. Distributed Subwoofers System. You basically have 3 small woofers (2 in front doors and one in cargo) that provide bass for the whole cabin. Contrast this to the traditional setup where you have only one subwoofer all the way in the back. Since most music rarely go below 40 Hz, this DSS system works great (and makes perfect sense)...no need for 12" or 15" subwoofer. But, by having 3 subs together, you can push out pretty good amount of bass throughout the cabin. And the smaller diameter woofers is able to give you cleaner (faster moving woofers vs. a large one) bass...maybe not as deep, but again, not needed for most music. Although bass technically cannot be localized, your ears/body can still localize it thru the energy being pumped out...so, in a traditional setup in a car, you need to ramp up the subwoofer in the cargo area so that the front passengers can "feel/hear" it. Of course, this kills the rear passengers because they can feel constant bass from the back of their heads. And for front passengers, you can still feel that bass is from the back of your head vs. being surrounded in bass. With Toyota/Lexus DSS, this localization of bass is eliminated.
(It is only for movies [bomb explosions!] that you need a big [large diameter] subwoofer.)